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Phage Therapy Application to Counteract Pseudomonas aeruginosa Infection in Cystic Fibrosis Zebrafish Embryos

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Published on: May 12, 2020

Phage therapy for Acinetobacter baumannii infection.

Ramneet Kaur¹, Dibita Mandal², Ajay Kumar³

¹Department of Basic and Applied Sciences, RIMT University, Punjab, India.

Progress in Molecular Biology and Translational Science

|September 22, 2023

Summary

Acinetobacter bacteria exhibit significant antibiotic resistance, making infections difficult to treat. Phage therapy offers a promising alternative, targeting these resistant bacteria effectively with specific bacteriophages.

Keywords:

Acinetobacter Bacteriophage Carbapenem resistant Combination therapy Multidrug resistant Phage therapy

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Area of Science:

Microbiology
Bacteriology
Infectious Diseases

Background:

Acinetobacter is a gram-negative nosocomial pathogen known for its high levels of antibiotic resistance.
The increasing prevalence of multidrug-resistant Acinetobacter complicates treatment strategies for hospital-acquired infections.

Purpose of the Study:

To review recent advancements in phage therapy as a viable treatment option against Acinetobacter infections.
To explore the mechanisms and effectiveness of various bacteriophages and their components in combating antibiotic-resistant Acinetobacter.

Main Methods:

Elaboration on various phage therapy approaches currently in use.
Discussion of phage propagation methods and resistance mechanisms.
Analysis of specific bacteriophages including Acibel004, Acibel007, vB-GEC_Ab-M-G7, ZZ1, and Bacteriophage p54 with Endolysin LysAB54.

Main Results:

Phage therapy demonstrates efficacy against carbapenem-resistant Acinetobacter strains.
Specific bacteriophages and endolysins show potential for targeted bacterial infection treatment.
Understanding phage propagation and resistance is crucial for therapeutic success.

Conclusions:

Phage therapy presents a potent strategy to overcome antibiotic resistance in Acinetobacter infections.
The use of specific bacteriophages and their lytic enzymes offers a promising avenue for novel antimicrobial treatments.
Further research into phage-host interactions and resistance is essential for clinical application.