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Lessons Learned From Global Hepatitis C Elimination Programs.

Senad Handanagic1, Shaun Shadaker1, Jan Drobeniuc1

  • 1Centers for Disease Control and Prevention, Division of Viral Hepatitis, Atlanta, Georgia, USA.

The Journal of Infectious Diseases
|September 22, 2023
PubMed
Summary
This summary is machine-generated.

Decentralized and integrated models significantly increased hepatitis C virus (HCV) testing access in Georgia, Rwanda, and Nigeria. These strategies are crucial for achieving global HCV elimination goals by 2030.

Keywords:
GeorgiaNigeriaRwandahepatitis Cviral hepatitis elimination

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Area of Science:

  • Public Health
  • Infectious Diseases
  • Global Health

Background:

  • The World Health Organization set 2030 targets to eliminate hepatitis C virus (HCV) as a public health threat.
  • Despite progress, only 23% of global HCV infections were diagnosed in 2020, highlighting a critical gap in testing and care access.
  • Decentralized and integrated healthcare models offer a promising approach to overcome testing barriers.

Purpose of the Study:

  • To examine how decentralized and integrated models have improved access to HCV testing in global health programs.
  • To highlight successful strategies implemented in Georgia, Rwanda, and Nigeria for HCV testing and linkage to care.
  • To inform future strategies for achieving the 2030 HCV elimination targets.

Main Methods:

  • Analysis of hepatitis C program data and strategies from Georgia, Rwanda, and Nigeria.
  • Focus on the implementation of decentralized testing and integrated service delivery models.
  • Inclusion of specific testing technologies like HCV core antigen and point-of-care (POC) HCV RNA testing.

Main Results:

  • Georgia achieved high screening rates (80% of adults) and treatment initiation through simplified testing and POC utilization.
  • Rwanda met its screening target and initiated treatment by rapidly decentralizing and integrating HCV services.
  • Nigeria's integrated near-POC testing approach expanded HCV viremia testing access, enabling same-day testing and treatment initiation.

Conclusions:

  • Decentralized and integrated HCV testing models are effective in increasing access and linkage to care.
  • Successful implementation in Georgia, Rwanda, and Nigeria provides valuable insights for other countries aiming for HCV elimination.
  • These strategies are vital for meeting the global 2030 hepatitis C elimination goals.