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Published on: August 5, 2022
Detection, mechanisms, and therapeutic implications of oncometabolites
Ying Cai1, Zhibo Wang1, Sifan Guo1
1International Advanced Functional Omics Platform, Scientific Experiment Center, Hainan General Hospital, Key Laboratory of Tropical Cardiovascular Diseases Research of Hainan Province, International Joint Research Center on Traditional Chinese and Modern Medicine, Hainan Medical University, Haikou 571199, China; Graduate School, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Abstract:
Metabolic abnormalities are a hallmark of cancer cells and are essential to tumor progression. Oncometabolites have pleiotropic effects on cancer biology and affect a plethora of processes, from oncogenesis and metabolism to therapeutic resistance. Targeting oncometabolites, therefore, could offer promising therapeutic avenues against tumor growth and resistance to treatments. Recent advances in characterizing the metabolic profiles of cancer cells are shedding light on the underlying mechanisms and associated metabolic networks. This review summarizes the diverse detection methods, molecular mechanisms, and therapeutic targets of oncometabolites, which may lead to targeting oncometabolism for cancer therapy.
Insights
Cancer cells exhibit metabolic abnormalities crucial for tumor growth. Targeting oncometabolites, molecules affecting cancer processes and treatment resistance, presents a promising therapeutic strategy for cancer therapy.
Area of Science:
- Oncology
- Metabolic pathways
- Cancer biology
Background:
- Metabolic abnormalities are characteristic of cancer cells and drive tumor progression.
- Oncometabolites exert diverse effects on cancer, influencing oncogenesis, metabolism, and therapeutic resistance.
Purpose of the Study:
- To review detection methods, molecular mechanisms, and therapeutic targets of oncometabolites.
- To highlight the potential of targeting oncometabolism for cancer treatment.
Main Methods:
- Literature review of recent advances in cancer cell metabolic profiling.
- Analysis of molecular mechanisms and therapeutic strategies related to oncometabolites.
Main Results:
- Oncometabolites play a pleiotropic role in cancer biology.
- Understanding metabolic networks aids in identifying therapeutic vulnerabilities.
Conclusions:
- Targeting oncometabolites offers a promising avenue for combating tumor growth and overcoming treatment resistance.
- Further research into oncometabolism can lead to novel cancer therapies.
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