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Author Spotlight: Development and Evaluation of a Standardized Rat Model for Calvarial Suture-Bony Composite Defects
Published on: May 10, 2024
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Delayed Presentation of Sagittal Suture Craniosynostosis
Rishi N Modi1, Caitlyn C Belza1, George N Kamel
1From the UC San Diego School of Medicine.
Annals of Plastic Surgery
|September 23, 2023
Summary
The saddle phenotype of sagittal craniosynostosis is linked to developmental delay and minor suture fusion. This phenotype also leads to older presentation age and more complex surgical outcomes.
Area of Science:
- Pediatric Neurosurgery
- Craniofacial Surgery
- Developmental Biology
Background:
- Sagittal craniosynostosis presents as dolichocephaly or saddle-shaped (clinocephaly) phenotypes.
- Understanding differences between these phenotypes and delayed presentation is crucial.
Purpose of the Study:
- To characterize clinical differences between sagittal synostosis phenotypes.
- To investigate the etiology of delayed presentation in sagittal synostosis.
Main Methods:
- Retrospective review of 160 patients with single-suture sagittal craniosynostosis (1999-2018).
- Analysis of correlations between phenotype, presentation timing, minor suture fusion, developmental delay, and surgical approach.
Main Results:
- Saddle phenotype (30.6%) was associated with higher rates of developmental delay and minor suture fusion compared to dolichocephaly (69.4%).
- Patients with saddle phenotype presented later for surgery, underwent open cranial vault repair more often, experiencing increased blood loss, transfusion volume, and operative time.
Conclusions:
- Developmental delay and minor suture fusion are initial presentations of the saddle phenotype.
- The saddle phenotype correlates with minor squamous and sphenoid suture fusion.
- Delayed presentation in saddle synostosis leads to more complex surgical interventions.
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