Related Experiment Video
Updated: Jul 16, 2025
09:14
Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
12.2K
Recent progress on chiral extractants for enantioselective liquid-liquid extraction
Beibei Zhu1, Huiyun Qiu1, Chenlei Ma1
1College of Pharmaceutical Science, Zhejiang University of Technology, Moganshan Campus, Gongda Road 1, Huzhou 313200, China.
Journal of Chromatography. A
|September 23, 2023
Summary
Chiral separation is crucial for enantiopure compounds. Novel chiral extractants, like metal complexes and ionic liquids, enhance enantioselective liquid-liquid extraction efficiency and scalability.
Area of Science:
- Chemistry
- Separation Science
- Asymmetric Catalysis
Background:
- Increasing demand for enantiopure compounds necessitates advanced chiral separation techniques.
- Enantioselective liquid-liquid extraction (ELLE) is a promising method due to its efficiency and scalability.
- Development of effective chiral extractants is key to successful enantioselective liquid-liquid extraction.
Purpose of the Study:
- To review recent advancements in chiral extractants for enantioselective liquid-liquid extraction.
- To highlight novel materials like metal complexes, cyclodextrins, and ionic liquids.
- To discuss principles, equipment, and solvent systems in enantioselective liquid-liquid extraction.
Main Methods:
- Review of literature on chiral extractants developed in the past decade.
- Focus on materials derived from asymmetric catalysis.
- Examination of metal complexes, cyclodextrins, ionic liquids, tartrate acids, and crown ethers.
Main Results:
- Several novel chiral extractants show potential for enantioselective liquid-liquid extraction.
- Examples include chiral ionic liquids, modified cyclodextrins, and SPINOL-based phosphoric acid hosts.
- These extractants demonstrate high enantiorecognition performance.
Conclusions:
- Novel chiral extractants are critical for advancing enantioselective liquid-liquid extraction.
- Materials inspired by asymmetric catalysis offer diverse and effective separation solutions.
- Further research into these extractants will enhance chiral separation technologies.
More Related Videos
09:26Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
16.1K
06:45Author Spotlight: Optimizing Hollow-Fiber Membranes for Continuous Liquid-Liquid Extraction of Medium-Chain Fatty Acids
Published on: August 9, 2024
1.2K
Related Concept Videos
00:56Extraction: Advanced Methods
481
Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is...
481
01:05High-Performance Liquid Chromatography: Elution Process
528
In High-Performance Liquid Chromatography (HPLC), the elution process is critical to the separation of analytes and the quality of chromatographic results. Elution describes how compounds move through the column and separate based on their interactions with the mobile and stationary phases. This process determines the resolution, peak shape, and retention times in the chromatogram, which are essential for identifying and quantifying components in complex mixtures. Understanding the elution...
528
01:09Ion-Exchange Chromatography
573
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
573
02:30Racemic Mixtures and the Resolution of Enantiomers
18.5K
A racemic mixture, or racemate, is an equimolar mixture of enantiomers of a molecule that can be separated using their unique interaction with chiral molecules or media. Racemic mixtures are denoted by the (±)- prefix. This ‘optical rotation descriptor’ applies to the whole solution of a racemic mixture rather than a specific stereoisomer. Enantiomers typically have the same physical and chemical properties. Hence, they are not easily separable. However, enantiomers can exhibit...
18.5K
02:57Sharpless Epoxidation
4.1K
The conversion of allylic alcohols into epoxides using the chiral catalyst was discovered by K. Barry Sharpless and is known as Sharpless epoxidation. The use of a chiral catalyst enables the formation of one enantiomer of the product in excess. This chiral catalyst is mainly a chiral complex of titanium tetraisopropoxide and tartrate ester (specific stereoisomer). The stereoisomer used in the chiral catalyst dictates the formation of the enantiomer of the product. In other words, the use of...
4.1K
01:11High-Performance Liquid Chromatography: Introduction
2.1K
High-performance liquid chromatography(HPLC), formerly referred to as High-pressure liquid chromatography, is a powerful technique used to separate, identify, and quantify components in complex mixtures. The term "high pressure" refers to using high pressure to push the liquid mobile phase through the tightly packed columns.
In HPLC, two phases play a critical role in the separation process:
In HPLC, two phases play a critical role in the separation process:
2.1K