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β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis
Jesús Isimar Serafín-Fabian1, Ma Elena Moreno-Godínez2, Eugenia Flores-Alfaro1
1Facultad de Ciencias Químico-Biológicas, Laboratorio de Epidemiología Clínica y Molecular, Universidad Autónoma De Guerrero, Guerrero, Mexico.
Introduction:
The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides.
Objective:
This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels.
Methods:
A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed.
Results:
Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels.
Conclusions:
The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure).
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