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Updated: Jul 15, 2025

A Fluorescence-based Assay of Phospholipid Scramblase Activity
Published on: September 20, 2016
Plant P4-ATPase lipid flippases: How are they regulated?
Richard Villagrana1, Rosa Laura López-Marqués1
1Copenhagen Plant Science Centre, Department of Plant and Environmental Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Abstract:
P4 ATPases are active membrane transporters that translocate lipids towards the cytosolic side of the biological membranes in eukaryotic cells. Due to their essential cellular functions, P4 ATPase activity is expected to be tightly controlled, but fundamental aspects of the regulation of plant P4 ATPases remain unstudied. In this mini-review, our knowledge of the regulatory mechanisms of yeast and mammalian P4 ATPases will be summarized, and sequence comparison and structural modelling will be used as a basis to discuss the putative regulation of the corresponding plant lipid transporters.
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