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Adenosine A2A receptors and sleep
Mustafa Korkutata1, Michael Lazarus2
1Department of Neurology, Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
International Review of Neurobiology
|September 23, 2023
Summary
Adenosine A2A receptors regulate sleep. This review explores agonists, antagonists, and modulators, including natural compounds, for sleep disorders.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Adenosine is an endogenous somnogen that influences sleep through A1 and A2A receptors.
- The adenosine A2A receptor's role in sleep-wake regulation is a key area of research.
Conclusions:
- Adenosine A2A receptor modulators offer potential therapeutic strategies for sleep disorders.
- Allosteric modulators may provide advantages over traditional agonists and antagonists for treating sleep and neurologic conditions.
- Further research is needed to fully elucidate the therapeutic benefits of A2A receptor-targeting compounds.
Keywords:
Adenosine A(2A) receptor agonistsAdenosine A(2A) receptor allosteric modulatorsAdenosine A(2A) receptor antagonistsAdenosine A(2A) receptorsCaffeineDrug developmentSlow-wave sleepMore Related Videos
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