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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Gene Therapy00:59

Gene Therapy

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Related Experiment Video

Updated: Jul 15, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
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A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy

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Chimeric antigen receptor therapy meets mRNA technology.

Jiacai Wu1, Weigang Wu2, Boping Zhou1

  • 1Department of Infectious Disease, Shenzhen People's Hospital, The First Affiliated Hospital of Southern University of Science and Technology and The Second Clinical Medical College of Jinan University, Shenzhen 518020, China; School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, China.

Trends in Biotechnology
|September 23, 2023
PubMed
Summary

Messenger RNA (mRNA)-encoded chimeric antigen receptors (CARs) offer a novel approach to cancer immunotherapy. This innovative method enables in vivo generation of CAR cells, advancing the development of next-generation living drugs.

Keywords:
chimeric antigen receptordelivery systemimmune cellimmunotherapymRNA

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Area of Science:

  • Immunology
  • Oncology
  • Biotechnology

Background:

  • Chimeric antigen receptor (CAR) T cell therapy has shown success in treating blood cancers.
  • Research is exploring other CAR immune cells for solid tumor treatment.
  • Messenger RNA (mRNA) therapeutics present a promising new class of medical treatments.

Purpose of the Study:

  • To review recent advancements in mRNA-based CAR immunotherapies.
  • To highlight the potential and challenges of mRNA-encoded CARs for cancer treatment.
  • To discuss the development of novel living drugs using mRNA technology.

Main Methods:

  • Review of current scientific literature on mRNA-based CAR immunotherapies.
  • Analysis of clinical and preclinical data for CAR immune cell therapies.
  • Exploration of mRNA technology for in vivo CAR cell generation.

Main Results:

  • mRNA-encoded CARs enable in vivo generation of CAR cells.
  • This approach avoids transgene integration, offering a safer alternative.
  • mRNA-based CARs represent a significant advancement in immunotherapy.

Conclusions:

  • mRNA-based CAR immunotherapies are a rapidly evolving field with vast potential.
  • This technology opens new avenues for treating various cancers and other diseases.
  • Further research is needed to overcome challenges and fully realize the potential of mRNA-based CARs as living drugs.