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Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Th17 Inflammation Model of Oropharyngeal Candidiasis in Immunodeficient Mice

Published on: February 18, 2015

STING negatively regulates antifungal immunity.

Yebo Gu¹, Xin-Ming Jia²

¹Department of Stomatology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China.

Trends in Microbiology

|September 23, 2023

Summary

Stimulator of interferon genes (STING) protects against viruses but hinders antifungal immunity. In fungal infections, STING moves to the phagosome, inhibiting immune responses against Candida albicans.

Keywords:

STING antifungal immunity negative regulation

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Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy

Assessing Anti-fungal Activity of Isolated Alveolar Macrophages by Confocal Microscopy

Published on: July 9, 2014

Area of Science:

Immunology
Mycology
Molecular Biology

Background:

Stimulator of interferon genes (STING) is crucial for antiviral immunity.
Its role in fungal infections remains largely uncharacterized.

Purpose of the Study:

To elucidate the function of STING in the context of fungal infections, specifically against Candida albicans.

Main Methods:

Investigated STING localization within host cells during fungal infection.
Analyzed the impact of STING on immune signaling pathways, including Syk phosphorylation.
Utilized cellular and molecular techniques to assess immune response regulation.

Main Results:

STING translocates to the phagosome during Candida albicans infection.
STING negatively regulates the immune response against this fungal pathogen.
This regulation occurs via the inhibition of Src-involved Syk phosphorylation.

Conclusions:

STING plays a distinct, inhibitory role in antifungal immunity, contrasting its antiviral function.
Targeting STING-mediated pathways could offer novel therapeutic strategies for fungal infections.