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[Paraneoplastic polymyalgia rheumatica. Case contribution].

P Manganelli, L Borghi, P Coruzzi

    Minerva Medica
    |October 6, 1986
    PubMed
    Summary
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    Polymyalgia rheumatica (PMR) can mimic digestive cancers. Early cancer detection requires careful evaluation and long-term monitoring, especially when PMR symptoms do not respond to steroid treatment.

    Area of Science:

    • Rheumatology
    • Gastroenterology
    • Oncology

    Background:

    • Polymyalgia rheumatica (PMR) is an inflammatory condition primarily affecting the elderly.
    • PMR typically shows high responsiveness to corticosteroid therapy.
    • PMR can be associated with giant cell arteritis and underlying malignancy.

    Observation:

    • Three cases are presented where digestive system cancers initially mimicked idiopathic PMR.
    • These neoplasms presented with symptoms similar to PMR but exhibited poor response to steroid treatment.
    • In one case, the primary malignancy was only identified during autopsy.

    Findings:

    • Malignant neoplasms of the digestive apparatus can present with clinical features resembling polymyalgia rheumatica.
    • A lack of response to steroid therapy in suspected PMR cases warrants further investigation for underlying malignancy.

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  • Digestive cancers may remain undiagnosed initially, even with PMR-like symptoms.

    • Implications:

    • These findings underscore the importance of thorough clinical evaluation for patients presenting with PMR-like symptoms.
    • Extended follow-up is crucial for accurate diagnosis, particularly in cases unresponsive to standard PMR treatment.
    • Considering malignancy in the differential diagnosis of PMR is essential for timely and appropriate patient management.