Related Experiment Video

Updated: Jul 15, 2025

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
04:37

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections

Published on: February 2, 2024

857

Organism profile and C-reactive protein (CRP) response are different in periprosthetic joint infection in patients

Mustafa Akkaya1, Serhat Akcaalan1, Fabio Luigi Perrone1

  • 1Department of Orthopaedic Surgery, Helios ENDO-Klinik, Holstenstr. 2, 22767, Hamburg, Germany.

Archives of Orthopaedic and Trauma Surgery
|September 24, 2023
PubMed

Insights

Patients with hepatitis B and C undergoing knee or hip replacement have a higher risk of periprosthetic joint infection (PJI). Gram-negative bacteria are more common in hepatitis patients with PJI, and their C-reactive protein (CRP) levels are lower.

Area of Science:

  • Orthopedic Surgery
  • Infectious Diseases
  • Hepatology

Background:

  • Hepatitis B and C are common conditions.
  • Patients with hepatitis undergoing total knee and hip arthroplasty face increased risks.
  • Periprosthetic joint infection (PJI) is a significant concern in these patients.

Purpose of the Study:

  • To investigate differences in PJI cases among patients with hepatitis B and C.
  • To compare PJI characteristics between hepatitis patients and a control group.

Main Methods:

  • Retrospective case-controlled study of 270 patients undergoing one-stage septic exchange for hip and knee joints.
  • Evaluation of surgical history, causative organisms, C-reactive protein (CRP) levels, and demographics.
  • Separate microbiological and laboratory analyses for knee and hip arthroplasty.

Main Results:

  • Mean CRP levels in hepatitis patients with knee PJI were significantly lower (23.6 mg/L) than in the control group (43.1 mg/L).
  • Gram-negative organisms were more frequently identified in hepatitis patients with PJI in both hip and knee joints.
  • Statistical significance was observed for CRP levels (p=0.004) and Gram-negative infections (p=0.041/p=0.044).

Conclusions:

  • Periprosthetic joint infections caused by Gram-negative bacteria are more prevalent in hepatitis patients.
  • Hepatitis patients exhibit a less pronounced C-reactive protein elevation compared to controls with PJI.
  • Individualized patient evaluation is crucial for managing PJI in individuals with co-existing hepatitis.
Abstract

Keywords:
ArthroplastyHepatitisPeriprosthetic joint infectionSeptic exchange

More Related Videos

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.2K
Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice08:32

Induction of an Inflammatory Response in Primary Hepatocyte Cultures from Mice

Published on: March 10, 2017

10.1K

Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
110
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
9
Pericarditis I: Introduction01:22

Pericarditis I: Introduction

Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
11
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K