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Updated: Jul 15, 2025

3D Printing of Biomolecular Models for Research and Pedagogy
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The NIAID/RNCP Biodosimetry Program: An Overview.

Merriline M Satyamitra1, David R Cassatt1, Olivia Molinar-Inglis1

  • 1Radiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology, and Transplantation (DAIT), U.S. Department of Health and Human Services (HHS), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, USA.

Cytogenetic and Genome Research
|September 24, 2023
PubMed
Summary

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The Radiation and Nuclear Countermeasures Program (RNCP) advances medical countermeasures and biodosimetry tools for radiation exposure. Their goal is to develop accurate, FDA-cleared biodosimetry devices to improve patient outcomes and save lives.

Area of Science:

  • Medical Countermeasures
  • Biodosimetry
  • Radiation Health

Background:

  • The Radiation and Nuclear Countermeasures Program (RNCP) was established in 2004 by the National Institute of Allergy and Infectious Diseases (NIAID).
  • The program focuses on developing medical countermeasures and biodosimetry technologies for acute radiation syndrome and delayed effects.
  • No biodosimetry device has yet received FDA clearance for use during radiological or nuclear incidents.

Purpose of the Study:

  • To advance medical countermeasure mitigators/therapeutics for radiation exposure.
  • To develop and validate biomarkers and technologies for assessing and managing radiation injuries.
  • To support the FDA clearance process for novel biodosimetry devices and assays.

Main Methods:

  • Conducting basic research to identify novel biodosimetry approaches.
Keywords:
Biodosimetry assaysDefinitive doseMechanismsPredictive biodosimetryResourcesTriage

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Last Updated: Jul 15, 2025

3D Printing of Biomolecular Models for Research and Pedagogy
09:17

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Published on: March 13, 2017

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  • Supporting advanced development and FDA clearance studies for triage and treatment devices.
  • Characterizing biomarkers and assays to predict radiation injury outcomes.
  • Facilitating outreach for developing cutting-edge biodosimetry methods.

    • Main Results:

    • The RNCP has actively funded research and development through various mechanisms, including grants and Small Business Innovation Research awards.
    • Progress is being made in advancing radiation biomarkers and biodosimetry approaches towards FDA clearance.
    • The program aims to align development with FDA guidance for Radiation Biodosimetry Medical Countermeasure Devices.

    Conclusions:

    • The ultimate goal is to establish accurate and reliable biodosimetry tools for improved radiation preparedness.
    • Development of these tools is crucial for saving lives during radiological or nuclear incidents.
    • Continued research and development are essential to achieve FDA clearance for biodosimetry devices.