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Cerebral Small Vessel Disease Is Associated with Motor, Cognitive, and Emotional Dysfunction in Multiple System
Xiao-Li Yang1, Yu Guo2, Shu-Fen Chen2
1Department of Neurology, Shanghai Fifth People's Hospital, Fudan University, Shanghai, China.
Journal of Parkinson'S Disease
|September 24, 2023
Summary
Cerebral small vessel disease (CSVD) is more prevalent in multiple system atrophy (MSA) patients. This increased burden is linked to greater motor, cognitive, and emotional impairments in individuals with MSA.
Area of Science:
- Neurology
- Neuroimaging
- Neurodegenerative Diseases
Background:
- Cerebral small vessel disease (CSVD) has not been systematically studied in multiple system atrophy (MSA).
- Understanding the relationship between CSVD and MSA is crucial for patient management.
Purpose of the Study:
- To investigate the prevalence of CSVD in MSA patients compared to healthy controls.
- To explore the association between CSVD burden and motor, cognitive, and emotional dysfunction in MSA.
Main Methods:
- 190 MSA patients and 190 matched controls were recruited.
- CSVD markers (WMH, microbleeds, lacunes, EPVS) were assessed using neuroimaging.
- Motor, cognitive, and emotional outcomes were evaluated in 118 MSA patients.
Main Results:
- MSA patients exhibited a higher burden of overall CSVD, white matter hyperintensity (WMH), and enlarged perivascular spaces (EPVS) than controls.
- Severe CSVD correlated with worse motor and cognitive function.
- WMH was associated with motor, cognitive, and emotional deficits; EPVS showed region-specific correlations with motor, anxiety, and cognitive symptoms.
Conclusions:
- Concomitant CSVD is associated with increased multi-dimensional dysfunction in patients with MSA.
- CSVD imaging markers have distinct relationships with specific MSA symptoms.
