A multifunctional and self-adaptive double-layer hydrogel dressing based on chitosan for deep wound repair

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Hydrogel wound dressings are crucial for repairing irregular and deep wounds.
• Developing self-adaptive hydrogels with enhanced therapeutic delivery is a key research area.

Purpose of the Study:

• To construct and evaluate a multifunctional, self-adaptive double-layer hydrogel for deep wound repair.
• To investigate the properties and efficacy of a chitosan-based inner layer and gellan gum-based outer layer hydrogel.

Main Methods:

• Fabrication of a double-layer hydrogel comprising a chitosan-based inner layer and a gellan gum-based outer layer.
• Systematic investigation of the inner layer's injectability, shape-adaptability, phase transition, biocompatibility, hemostasis, and antimicrobial/anti-inflammatory properties.
• Evaluation of the outer layer's mechanical strength and moisture-retaining capabilities.

Main Results:

• The inner layer hydrogel demonstrated a solid-to-liquid phase transition at body temperature, enabling superior adaptability for irregular and deep wound filling.
• Chitosan liquefaction in the inner layer maximized therapeutic effects.
• The outer layer provided mechanical protection and maintained a moist wound environment.
• The double-layer hydrogel significantly promoted skin tissue regeneration and accelerated wound closure.

Conclusions:

• The developed double-layer hydrogel exhibits excellent self-adaptive and therapeutic properties for deep wound management.
• This hydrogel shows significant potential for clinical application as an advanced wound dressing for complex wounds.