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Updated: Jul 15, 2025

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Sequence tolerance of immunoglobulin variable domain framework regions to noncanonical intradomain disulfide linkages

Dae Young Kim1, Hiba Kandalaft1, Michael J Lowden1

  • 1Life Sciences Division, Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, Ontario, Canada.

The Journal of Biological Chemistry
|September 24, 2023
PubMed

Keywords:
disulfideimmunoglobulin variable domainphage displayprotein engineeringprotein stabilitysingle-domain antibody (sdAb, nanobody)

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