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[Maternal nutritional factors and environmental exposure in early life and childhood atopic dermatitis]

Y Ye1, L M Dou1, L H Wang1

  • 1Department of Dermatology, Children's Hospital of Fudan University, Shanghai 201102, China.

Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]
|September 24, 2023
PubMed

Insights

Maternal nutrition and environmental exposures during pregnancy may influence childhood atopic dermatitis (AD). Understanding these early life factors is crucial for preventing this chronic inflammatory skin condition.

Area of Science:

  • Dermatology
  • Immunology
  • Pediatrics

Context:

  • Atopic dermatitis (AD) is a prevalent, chronic inflammatory skin condition in children, significantly impacting quality of life.
  • The exact pathogenesis of AD remains unclear, but involves genetic and environmental factors leading to skin barrier dysfunction and immune dysregulation.

Purpose:

  • To review recent research on the impact of maternal nutritional factors and in-utero environmental exposures on the development of atopic dermatitis in offspring.
  • To explore the hypothesis that allergic diseases originate during the fetal period, influenced by maternal exposures.

Summary:

  • Early life exposures, including maternal nutrition (folate, vitamins D and E, polyunsaturated fatty acids) and environmental factors (tobacco, home environment) during pregnancy, are increasingly linked to childhood AD.
  • This review focuses on the relationship between maternal nutritional status and family environmental exposures during gestation and their subsequent effects on offspring's risk of developing atopic dermatitis.

Impact:

  • Highlights the critical role of the intrauterine environment and maternal health in shaping offspring's susceptibility to atopic dermatitis.
  • Provides insights for potential early intervention strategies targeting maternal exposures to mitigate childhood AD risk.

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