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The Retinoblastoma Gene

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...

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Updated: Jul 15, 2025

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Intracranial Orthotopic Allografting of Medulloblastoma Cells in Immunocompromised Mice

Published on: October 3, 2010

[Medulloblastoma].

Shigeru Yamaguchi¹, Miki Fujimura

¹Department of Neurosurgery, Faculty of Medicine, Hokkaido University.

No Shinkei Geka. Neurological Surgery

|September 24, 2023

Summary

This summary is machine-generated.

The 5th edition WHO classification of medulloblastomas uses molecular subgroups (WNT, SHH, non-WNT/non-SHH) instead of histopathology. This new pediatric brain tumor classification aids in understanding prognosis and developing targeted treatments.

Area of Science:

Pediatric neuro-oncology
Molecular pathology of brain tumors

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