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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
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Author Spotlight: Advancing Research Through Single Cell Sequencing and Spatial Histology in Placental Tissues
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Artificial placenta technology: History, potential and perception.

H Usuda1, S Watanabe2, Hanita T2

  • 1Division of Obstetrics and Gynaecology, The University of Western Australia, Perth, Western Australia, Australia; Centre for Perinatal and Neonatal Medicine, Tohoku University Hospital, Sendai, Japan.

Placenta
|September 25, 2023
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Summary

The artificial placenta (AP) supports extremely preterm infants by oxygenating fetal blood via external gas exchangers. This review details the 60-year development of AP technology, highlighting its potential to improve outcomes for infants near the border of viability.

Keywords:
Artificial placentaExtremely preterm infantLife support[KEYWORDS]

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Area of Science:

  • Neonatal medicine
  • Biomedical engineering
  • Perinatal research

Background:

  • The artificial placenta (AP) is an experimental life support system for extremely preterm infants (21-23 weeks gestation).
  • It functions by oxygenating fetal blood through gas exchangers connected to the fetal vasculature, keeping the lungs fluid-filled and the fetus quiescent.
  • The development of AP technology spans six decades, evolving from external pump-driven systems to fetal heart-powered platforms.

Conclusions:

  • The artificial placenta (AP) represents a long-standing experimental approach with significant potential for improving outcomes in extremely preterm infants.
  • Continued research and accurate dissemination of findings are crucial as AP technology nears clinical reality.
  • Addressing misconceptions is vital to fully appreciating the transformative impact AP could have on neonatal survival and health.