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Emerging principles of primary cilia dynamics in controlling tissue organization and function
Jay Gopalakrishnan1, Kerstin Feistel2, Benjamin M Friedrich3
1Institute for Human Genetics, Heinrich-Heine-Universität, Universitätsklinikum Düsseldorf, Düsseldorf, Germany.
The EMBO Journal
|September 25, 2023
Summary
Primary cilia are dynamic organelles crucial for cell signaling and tissue development. Their assembly, disassembly, and molecular composition are key to integrating cellular inputs and controlling cell fate.
Area of Science:
- Cell Biology
- Developmental Biology
Background:
- Primary cilia are cellular organelles essential for sensing extracellular signals.
- They play a critical role in transducing signals into cellular responses.
Purpose of the Study:
- To review the emerging concept of primary cilia dynamics.
- To highlight the role of primary cilia dynamics in tissue development, organization, remodeling, and function.
Main Methods:
- Literature review of recent findings on primary cilia.
- Synthesis of information on primary cilia composition, sensing, and assembly/disassembly cycles.
Main Results:
- Primary cilia are not static but possess dynamic molecular composition.
- Cilia function relies on context-dependent sensing, stimulus processing, and cell/tissue-specific assembly/disassembly.
- Primary cilia dynamically integrate cellular inputs to control cell fate and function.
Conclusions:
- Primary cilia dynamics are fundamental to understanding tissue development and function.
- The dynamic nature of cilia is critical for their role in integrating cellular information.
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