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Updated: Jul 15, 2025
Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer
Published on: September 8, 2023
Advancement of regulating cellular signaling pathways in NSCLC target therapy via nanodrug
Wenqiang Li1, Mei Li2, Qian Huang3
1Zigong First People's Hospital, Zigong, Sichuan, China.
Abstract:
Lung cancer (LC) is one of the leading causes of high cancer-associated mortality worldwide. Non-small cell lung cancer (NSCLC) is the most common type of LC. The mechanisms of NSCLC evolution involve the alterations of multiple complex signaling pathways. Even with advances in biological understanding, early diagnosis, therapy, and mechanisms of drug resistance, many dilemmas still need to face in NSCLC treatments. However, many efforts have been made to explore the pathological changes of tumor cells based on specific molecular signals for drug therapy and targeted delivery. Nano-delivery has great potential in the diagnosis and treatment of tumors. In recent years, many studies have focused on different combinations of drugs and nanoparticles (NPs) to constitute nano-based drug delivery systems (NDDS), which deliver drugs regulating specific molecular signaling pathways in tumor cells, and most of them have positive implications. This review summarized the recent advances of therapeutic targets discovered in signaling pathways in NSCLC as well as the related NDDS, and presented the future prospects and challenges.
Insights
This review explores nano-based drug delivery systems (NDDS) for non-small cell lung cancer (NSCLC) treatment. It highlights therapeutic targets in signaling pathways and the potential of NDDS for improved cancer therapy.
Area of Science:
- Oncology
- Nanotechnology
- Molecular Biology
Background:
- Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality globally, driven by complex signaling pathway alterations.
- Despite advances, NSCLC treatment faces challenges in early diagnosis, therapy, and drug resistance.
- Targeted drug delivery and therapy based on molecular signals are crucial for overcoming these challenges.
Purpose of the Study:
- To review recent advances in identifying therapeutic targets within NSCLC signaling pathways.
- To summarize the development and application of nano-based drug delivery systems (NDDS) for NSCLC.
- To discuss future prospects and challenges in this field.
Main Methods:
- Literature review of recent studies on NSCLC signaling pathways.
- Analysis of research on nanoparticles (NPs) and nano-based drug delivery systems (NDDS).
- Synthesis of information on therapeutic targets and their regulation by NDDS.
Main Results:
- Numerous therapeutic targets in NSCLC signaling pathways have been identified.
- Various combinations of drugs and nanoparticles form effective NDDS for NSCLC.
- NDDS show positive implications for regulating specific molecular signaling pathways in tumor cells.
Conclusions:
- NDDS hold significant potential for the diagnosis and treatment of NSCLC.
- Targeting specific molecular signaling pathways with NDDS offers a promising therapeutic strategy.
- Further research is needed to address challenges and optimize NDDS for clinical application in NSCLC.
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