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Published on: November 8, 2024
The association between mean platelet volume and poor outcome in patients with COVID-19: Systematic review,
Ahmad Fariz Malvi Zamzam Zein1,2, Catur Setiya Sulistiyana3, Wilson Matthew Raffaelo4
1Department of Internal Medicine, Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia.
Insights
Increased mean platelet volume (MPV) is linked to severe COVID-19 outcomes and mortality. This finding suggests MPV could be a potential biomarker for disease severity. Further research is needed to establish optimal cut-off points.
Area of Science:
- Hematology
- Infectious Diseases
- Critical Care Medicine
Background:
- COVID-19 is a significant global health concern with varied clinical presentations.
- Mean Platelet Volume (MPV) is an indicator of platelet activation and function.
- The relationship between MPV and COVID-19 severity requires further elucidation.
Purpose of the Study:
- To assess the association between mean platelet volume (MPV) and poor outcomes in COVID-19 patients.
- To synthesize existing evidence through a meta-analysis.
Main Methods:
- A comprehensive literature search was conducted across PubMed, Embase, and Scopus databases.
- Keywords included "2019-nCoV", "SARS-CoV-2", "COVID-19", "mean platelet volume", and "MPV".
- The primary outcome was a composite of severe COVID-19 or mortality, with pooled effect estimates reported as mean differences.
Main Results:
- The meta-analysis included 17 studies with 4549 COVID-19 patients.
- Higher MPV was observed in patients with poor outcomes (10.3 ± 1.9 fL) compared to those without (9.9 ± 1.7 fL).
- Increased MPV was significantly associated with both severe COVID-19 and mortality, independent of age, gender, or other blood cell counts.
Conclusions:
- Elevated MPV is associated with increased severity and mortality in COVID-19 patients.
- MPV may serve as a potential prognostic biomarker for COVID-19.
- Further research is recommended to determine the optimal MPV cut-off for predicting adverse outcomes.
Introduction:
This study aims to assess the association between mean platelet volume (MPV) and poor outcome in patients with COVID-19.
Methods:
We performed a comprehensive literature search using the PubMed, Embase and Scopus databases with keywords "2019-nCoV" OR "SARS-CoV-2" OR "COVID-19" AND "mean platelet volume" OR "MPV" on 8 July 2021. The primary outcome was composite poor outcome, defined as severe COVID-19 or mortality. The pooled effect estimate was reported as mean differences in terms of MPV between the group with and without outcome.
Results:
There were 17 studies which consist of 4549 patients with COVID-19 were included in this study. The incidence of poor outcome was 25% (20%-30%). Mean MPV was found to be higher in the poor outcome group in compare to no poor outcome group (10.3 ± 1.9 fL vs 9.9 ± 1.7 fL). The mean MPV difference between both group was 0.47 fL [95% CI 0.27, 0.67], p < 0.001; I2: 62.91%, p < 0.001). In the sub-group analysis, patients with severe COVID-19 had higher MPV (mean difference 0.54 fL [95% CI 0.28, 0.80], p < 0.001; I2: 54.84%, p = 0.014). Furthermore, MPV was also higher in the mortality group (mean difference 0.54 fL [95% CI 0.29, 0.80], p = 0.020; I2: 71.11%, p = 0.004). Meta-regression analysis showed that the association between MPV and poor outcome was not affected by age (p = 0.789), gender (p = 0.167), platelets (p = 0.056), white blood cells (p = 0.639), and lymphocytes (p = 0.733).
Conclusion:
This meta-analysis indicated that increased MPV was associated with severity and mortality in patients with COVID-19. Further research is needed to determine the optimum cut-off point.
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