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Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
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Silver nanoparticle technology in orthopaedic infections.

Madhan Jeyaraman1,2, Naveen Jeyaraman1, Arulkumar Nallakumarasamy1

  • 1Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.

World Journal of Orthopedics
|September 25, 2023
PubMed
Summary

Antimicrobial resistance is a growing threat. Silver nanoparticle technology offers a promising nanotechnology approach to combat antibiotic-resistant orthopaedic infections by targeting infection sites.

Keywords:
Antimicrobial resistanceBiofilmsNanoparticlesOrthopaedicsSilver

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Area of Science:

  • Orthopaedic surgery
  • Nanomedicine
  • Antimicrobial resistance

Background:

  • Prolonged antibiotic use in orthopaedic infections fuels antimicrobial resistance.
  • Novel strategies are crucial to overcome this challenge.
  • Nanotechnology offers targeted infection eradication.

Purpose of the Study:

  • To review silver nanoparticle technology for orthopaedic infections.
  • To explore its mechanism, applications, toxicity, and regulations.

Main Methods:

  • Literature review of silver nanoparticle applications in orthopaedics.
  • Analysis of antimicrobial mechanisms.
  • Evaluation of clinical data and safety profiles.

Main Results:

  • Silver nanoparticles demonstrate broad-spectrum antimicrobial activity.
  • Potential for targeted delivery and reduced systemic toxicity.
  • Emerging clinical applications in bone infection treatment.

Conclusions:

  • Silver nanoparticles represent a viable nanotechnology-based strategy for orthopaedic infections.
  • Further research is needed to optimize clinical use and address regulatory aspects.