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Multi-biological functions of intermedin in diseases
Zhi Yang1,2, Hongchun Li3, Pengfei Wu4
1Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Frontiers in Physiology
|September 25, 2023
Summary
Intermedin (IMD), a CGRP/CT superfamily member, plays protective roles in various diseases and regulates tumor metastasis. Further research is needed to understand IMD peptide formation and signaling for clinical applications.
Area of Science:
- Biochemistry
- Molecular Biology
- Physiology
Background:
- Intermedin (IMD) belongs to the calcitonin gene-related peptide (CGRP)/calcitonin (CT) superfamily.
- IMD is widely expressed and interacts with CLR/RAMP receptor complexes, activating Gαs.
- IMD acts as a biomarker in tumor initiation and metastasis.
Purpose of the Study:
- To systematically review IMD's expression, structure, receptors, and signaling pathways.
- To elucidate IMD's comprehensive functions in various diseases, including AKI, obesity, diabetes, heart failure, and sepsis.
- To identify knowledge gaps regarding IMD's in vivo formation and downstream signaling.
Main Methods:
- Literature review of IMD's role in physiology and pathology.
- Analysis of IMD's involvement in angiogenesis and vascular development.
- Examination of IMD's protective effects in diverse disease models.
Main Results:
- IMD is a proangiogenic factor, regulating blood vessel formation and lumen expansion.
- IMD demonstrates protective functions in ischemia-reperfusion injury, metabolic, cardiovascular, and inflammatory diseases.
- IMD's roles in acute kidney injury, obesity, diabetes, heart failure, and sepsis are highlighted.
Conclusions:
- IMD is a multifaceted peptide with significant therapeutic potential.
- Understanding IMD's precise in vivo processing and signaling is crucial for clinical translation.
- Further research is warranted to fully harness IMD for medical applications.
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