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Pleiotropic Genetic Effects between Multiple Sclerosis and Musculoskeletal Traits.
Sohyun Jeong1,2, Ming-Ju Tsai1,2, Changbing Shen3,4
1Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston 02131, MA.
Medrxiv : the Preprint Server for Health Sciences
|September 25, 2023
Summary
Multiple Sclerosis (MS) shows a genetic link with falls, but not fractures or frailty. While MS and falls share genetic effects, MS does not causally increase the risk of falls, fractures, or frailty.
Area of Science:
- Genetics
- Neurology
- Orthopedics
Background:
- Musculoskeletal disorders are common in Multiple Sclerosis (MS) patients.
- The genetic basis linking MS and musculoskeletal issues is poorly understood.
- Genome-Wide Association Studies (GWAS) offer insights into shared genetic factors.
Conclusions:
- A potential genetic correlation exists between MS and falls.
- No evidence supports a causal relationship where MS increases the risk of falls, fracture, or frailty.
- Shared genetic factors may influence MS and fall risk.
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