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Dissociable contributions of the medial parietal cortex to recognition memory
Seth R Koslov1, Joseph W Kable2, Brett L Foster1
1Department of Neurosurgery, Perelman School of Medicine; University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
Biorxiv : the Preprint Server for Biology
|September 25, 2023
Summary
The medial parietal cortex (MPC) shows distinct functional subregions for recognition decisions versus semantic content during memory retrieval. This organization principle may apply across hippocampal-neocortical memory systems.
Area of Science:
- Neuroscience
- Cognitive Neuroscience
- Neuroimaging
Background:
- Episodic memory retrieval involves medial temporal lobe and medial parietal cortex (MPC).
- Distinct functional patterns within MPC during recognition memory and autobiographical recall suggest task-specific organization.
- Understanding MPC's role in memory-based decisions is crucial for memory research.
Approach:
- Utilized high-resolution 7T fMRI to analyze thousands of recognition memory trials.
- Identified subregions within MPC responsive to recognition decisions or semantic content.
- Examined connectivity patterns between MPC and the hippocampus during task and rest.
Key Points:
- Observed distinct, interleaved functional subregions in MPC sensitive to either recognition decisions or semantic content, but not both.
- Functional dissociation in MPC was amplified by differential connectivity with the hippocampus.
- Person and place selectivity in MPC reflects category-specific responses within semantic regions.
Conclusions:
- Distinct patterns of MPC responses during episodic retrieval are driven by task demands.
- Findings suggest a common organizational principle in hippocampal-neocortical memory systems.
- This research clarifies the functional organization of the medial parietal cortex in memory retrieval.
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