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Updated: Jul 15, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Mapping the Single-cell Differentiation Landscape of Osteosarcoma.

Danh D Truong¹, Corey Weistuch², Kevin A Murgas³

¹Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX.

Biorxiv : the Preprint Server for Biology

|September 25, 2023

Summary

This study maps human mesenchymal stem cell differentiation to understand osteosarcoma (OS) heterogeneity. A stem-like cell signature in OS tumors correlates with poorer survival, offering therapeutic targets.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

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Last Updated: Jul 15, 2025

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

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Published on: April 12, 2019

Author Spotlight: Exploring Advanced Therapeutic Targets in Osteosarcoma Through Spatial Transcriptomics

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

Oncology
Stem Cell Biology
Genetics

Background:

Osteosarcoma (OS) exhibits genetic and intratumoral heterogeneity, complicating drug development and the study of cell fate.
Understanding cell differentiation, plasticity, and fate is crucial for OS tumor grade, metastasis, and survival.

Conclusions:

This study provides the first accurate quantification of osteosarcoma differentiation and lineage commitment.
A stem-like transcriptomic signature is associated with adverse survival in osteosarcoma.
Understanding differentiation pathways is a critical prerequisite for developing targeted osteosarcoma therapies.