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Updated: Jul 15, 2025
07:51
Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
17.3K
Maternal IL-10 restricts fetal emergency myelopoiesis
Biorxiv : the Preprint Server for Biology
|September 25, 2023
Summary
Maternal interleukin-10 (IL-10) blocks fetal hematopoietic stem and progenitor cells (HSPCs) from activating emergency myelopoiesis, leading to neutropenia in newborns. This maternal anti-inflammatory response compromises fetal infection defense.
Area of Science:
- Immunology
- Developmental Biology
- Hematopoiesis
Background:
- Neonates exhibit heightened susceptibility to inflammation and infection compared to adults.
- Fetal hematopoietic stem and progenitor cells (HSPCs) are crucial for immune development but their response to inflammation is not fully understood.
Conclusions:
- Maternal IL-10 restricts fetal HSPCs from engaging EM pathways, impacting myeloid cell output.
- This restriction may explain neutropenia observed in septic neonates.
- An evolutionary trade-off exists between maintaining pregnancy via maternal anti-inflammatory factors and fetal immune responsiveness.
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