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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

11
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
11
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

9
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
9
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

11
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Related Experiment Video

Updated: Jul 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
09:06

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice

Published on: February 20, 2019

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Development and implementation of an integrated preclinical atherosclerosis database.

Rachel Xiang1, Yihua Wang1, Megan M Shuey2

  • 1Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA.

Biorxiv : the Preprint Server for Biology
|September 25, 2023
PubMed
Summary
This summary is machine-generated.

Integrating data from preclinical atherosclerosis mouse models can improve the translation of basic science discoveries into clinical advancements. This approach enables comprehensive analysis of gene functions in disease mechanisms.

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Related Experiment Videos

Last Updated: Jul 15, 2025

Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
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Area of Science:

  • Biomedical research
  • Translational science
  • Cardiovascular research

Background:

  • Preclinical animal models are crucial for understanding human disease mechanisms, yielding numerous publications but limited clinical translation.
  • An integrated analysis of existing studies offers a promising strategy to enhance translational success in medicine.

Approach:

  • Atherosclerosis was used as a model, extracting data from ApoE and LDLR knockout mouse studies published in key journals.
  • A comprehensive preclinical atherosclerosis database was created, including experimental conditions, interventions, and outcomes.
  • Standardized procedures and software tools were developed for data extraction, gene attribution, and transcriptomics analysis.

Key Points:

  • The database incorporates data on animal sex, diet, interventions, and plaque characteristics (size, inflammation, lipid content).
  • It integrates hundreds of genes tested in vivo for their causal role in murine atherosclerosis.
  • The database facilitates integrated analyses of decades of atherosclerosis research.

Conclusions:

  • The developed methods and software can be applied to other preclinical models for diverse human diseases.
  • Future applications include analyzing sub-datasets based on plaque pathology, cell type, or sex.
  • This integrated approach aims to unlock the full potential of preclinical data for mechanistic insights and clinical translation.