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Yeast Signaling

Yeast Signaling

Yeasts are single-celled organisms, but unlike bacteria, they are eukaryotes (cells with a nucleus). Cell signaling in yeast is similar to signaling in other eukaryotic cells. A ligand, such as a protein or a small molecule released from a yeast cell, attaches to a receptor on the cell surface. The binding stimulates second-messenger kinases to activate or inactivate transcription factors that further regulate gene expression. Many of the yeast intracellular signaling cascades have similar...

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Related Experiment Video

Updated: Jul 15, 2025

Targeted in Situ Mutagenesis of Histone Genes in Budding Yeast

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Published on: January 26, 2017

Tuning Interdomain Conjugation Toward in situ Population Modification in Yeast.

Kevin R Stindt, Megan N McClean

Biorxiv : the Preprint Server for Biology

|September 25, 2023

Summary

Researchers optimized interdomain conjugation (IDC), a method for transferring DNA between bacteria and yeast, by promoting bacterial commensalism. This breakthrough enables precise genetic modification of fungal populations within microbiomes for biotechnology applications.

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Area of Science:

Microbiome Engineering
Synthetic Biology
Fungal Biotechnology

Background:

Controlling microbial communities is vital for biotechnology and biomedicine.
Fungal modification technologies lag behind bacterial systems.
Interdomain conjugation (IDC) allows DNA transfer from bacteria to yeast for *in situ* modification.

Conclusions:

Optimized bacterial-yeast interactions, specifically commensalism, significantly enhance interdomain conjugation efficiency.
Cell-to-cell binding and population dynamics offer predictable control over IDC.
IDC is a powerful tool for engineering microbiomes, enabling targeted genetic modification of fungal populations for diverse applications.