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Updated: Jul 15, 2025
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A Mass Spectrometry-Based Approach to Identify Phosphoprotein Phosphatases and their Interactors
Published on: April 29, 2022
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Protein phosphatase 1 regulates core PCP signaling
Song Song1,2, Bomsoo Cho1, Alexis T Weiner1
1Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Biorxiv : the Preprint Server for Biology
|September 25, 2023
Summary
Protein Phosphatase 1 (PP1) regulates epithelial cell polarity by controlling core protein localization and phosphorylation. This study identifies PP1-87B as a key regulator in Drosophila, impacting Van Gogh asymmetry.
Area of Science:
- Cell Biology
- Developmental Biology
- Biochemistry
Background:
- Planar cell polarity (PCP) signaling establishes cell asymmetry within epithelial tissues.
- Core PCP components localize asymmetrically to mediate cell polarization and coordination.
- Post-translational modifications are crucial for achieving asymmetry, but identifying regulators is difficult.
Conclusions:
- Pp1-87B plays a significant role in regulating PCP by modulating core protein dephosphorylation and localization.
- Dynamic cycling between phosphorylated and unphosphorylated states of PCP components likely drives asymmetry.
- The study provides a valuable resource for discovering additional PCP regulators.
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