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A Single-cell and Spatial RNA-seq Database for Alzheimer's Disease (ssREAD).

Cankun Wang¹, Diana Acosta², Megan McNutt¹

¹Department of Biomedical Informatics, The Ohio State University, OH 43210, USA.

Biorxiv : the Preprint Server for Biology

|September 25, 2023

Summary

A new database, ssREAD, centralizes single-cell and spatial RNA sequencing data for Alzheimer's Disease (AD) research. It provides a vast resource and analytical tools to advance understanding of AD pathology at a cellular level.

Keywords:

Alzheimer’s Disease Spatial transcriptomics Web database single-cell and single-nucleus RNA sequencing

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Area of Science:

Neuroscience
Genomics
Bioinformatics

Background:

Alzheimer's Disease (AD) research increasingly utilizes single-cell and spatial transcriptomics.
Existing data repositories lack comprehensiveness and user-friendliness for these complex datasets.

Conclusions:

ssREAD serves as a valuable, user-friendly resource for Alzheimer's Disease research.
The database and its analytical tools will accelerate discoveries in AD pathology.
ssREAD promotes integrated analysis of multi-omic data in neurodegenerative disease research.