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Sub-second Dopamine Signals during Risky Decision-Making in Patients with Impulse Control Disorder.

Brittany Liebenow, Thomas Wilson, Benjamin Maas

    Biorxiv : the Preprint Server for Biology
    |September 25, 2023
    PubMed
    Summary

    Patients with Impulse Control Disorder (ICD) exhibit riskier financial decisions and faster dopamine level changes in the brain. These findings in Parkinson's disease patients highlight rapid dopamine signaling during decision-making.

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    Area of Science:

    • Neuroscience
    • Behavioral Science
    • Pharmacology

    Background:

    • Impulse Control Disorder (ICD) in Parkinson's disease is a behavioral addiction linked to dopaminergic therapies.
    • Previous research suggests altered striatal function and dopamine activity in patients with ICD.
    • Existing studies lack the temporal resolution to examine real-time dopamine signaling during decision-making.

    Conclusions:

    • Parkinson's disease patients with ICD exhibit increased risky behavior and heightened, rapid dopamine signaling during decision-making, even when medication-free.
    • Observed dopamine signaling may reflect an inherent predisposition or a consequence of prior ICD.
    • Future research on dopamine in cognition and disease should incorporate sub-second temporal dynamics.