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Related Concept Videos

Factors Influencing Microbial Growth: Temperature01:27

Factors Influencing Microbial Growth: Temperature

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Microorganisms display remarkable adaptations, enabling them to thrive in diverse ecological niches across a wide range of temperatures. Temperature profoundly influences microbial growth by affecting enzymatic activity, membrane fluidity, and other cellular processes.Each microorganism operates within a specific temperature range defined by three cardinal points: minimum, optimum, and maximum. Below the minimum temperature, membranes lose fluidity, halting transport processes. Above the...
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Effect of Temperature Change on Reaction Rate02:28

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The Arrhenius equation,
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Physical Methods for Controlling Microbial Growth: Temperature01:23

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Heat is a widely used method to control microbial growth by targeting and denaturing cellular proteins, thereby killing or inactivating microbes. This method's effectiveness is quantified using parameters such as the thermal death point (TDP), thermal death time (TDT), and decimal reduction time (D value). TDP represents the lowest temperature at which all microorganisms in a liquid suspension are eliminated within 10 minutes, whereas TDT is the time necessary to achieve sterilization at a...
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Effects of Temperature on Free Energy02:11

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The spontaneity of a process depends upon the temperature of the system. Phase transitions, for example, will proceed spontaneously in one direction or the other depending upon the temperature of the substance in question. Likewise, some chemical reactions can also exhibit temperature-dependent spontaneities. To illustrate this concept, the equation relating free energy change to the enthalpy and entropy changes for the process is considered:
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Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Factors Affecting Body Temperature01:28

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As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
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Determining Viral Disinfection Efficacy of Hot Water Laundering
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Effect of elevated temperature on SARS-CoV-2 viability.

Harapan Harapan1,2,3, Edison Johar4, Chairin Nisa Maroef4

  • 1Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia.

F1000Research
|September 25, 2023
PubMed
Summary

Elevating temperature to 40°C significantly reduces SARS-CoV-2 viability, while 55°C eliminates it. This finding supports using heat for both patient thermotherapy and isolation chamber sterilization to combat COVID-19.

Keywords:
COVID-19Isolation chamberSARS-CoV-2TemperatureTransmission

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Area of Science:

  • Virology
  • Infectious Diseases
  • Biomedical Engineering

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a significant risk to healthcare workers.
  • Developing effective isolation chambers is crucial for reducing virus transmission during patient treatment.
  • Understanding viral inactivation through environmental factors like temperature is key to designing better containment strategies.

Purpose of the Study:

  • To evaluate the efficacy of elevated temperatures in reducing SARS-CoV-2 viability.
  • To gather data for optimizing the design of isolation chambers for COVID-19 patients.
  • To explore the potential of mild hyperthermia as a therapeutic approach.

Main Methods:

  • Incubation of SARS-CoV-2 (Indonesian isolate) at temperatures ranging from 25°C to 65°C for one hour.
  • Assessment of viral viability using plaque assays on Vero E6 cells.
  • Comparison of viral titers at different temperature points and room temperature controls.

Main Results:

  • A significant reduction in SARS-CoV-2 viability (from 10^13 PFU/mL to 10^9 PFU/mL) was observed at 40°C.
  • Temperatures of 55°C and above completely eliminated viral viability.
  • The study demonstrated a clear dose-dependent relationship between temperature elevation and viral inactivation.

Conclusions:

  • Elevated temperatures, particularly 55°C, can effectively sterilize isolation chambers.
  • Mild hyperthermia (around 40°C) may offer a therapeutic benefit for COVID-19 patients by reducing viral load.
  • Temperature control is a critical factor in developing optimized isolation chambers for managing SARS-CoV-2 infections.