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Assessment of open-field fluorescence guided surgery systems: implementing a standardized method for characterization
Marien I Ochoa1, Alberto Ruiz2, Ethan LaRochelle2
1University of Wisconsin Madison, Department of Medical Physics, Madison, Wisconsin, United States.
Journal of Biomedical Optics
|September 25, 2023
Summary
Standardizing fluorescence guided surgery (FGS) systems is crucial for improving surgical decision-making and patient outcomes. This study proposes and validates a pipeline for evaluating FGS systems, enabling better inter-system comparisons and next-generation development.
Area of Science:
- Medical Imaging
- Surgical Technology
- Biophotonics
Background:
- Fluorescence guided surgery (FGS) enhances surgical decision-making and patient outcomes across various procedures.
- FGS systems offer improved tissue perfusion accuracy and real-time functional characterization.
- Despite FDA clearance for multiple FGS devices, a lack of standardization methods hinders widespread adoption and comparison.
Purpose of the Study:
- To overview commonalities in optical imaging methods for FGS standardization.
- To propose and execute a system evaluation pipeline for fluorescence guided surgery devices.
- To facilitate inter-system comparisons and understanding of FGS system features.
Main Methods:
- Developed a standardization pipeline evaluating key imaging characteristics.
- Utilized photo-stable indocyanine green fluorescence phantoms for evaluation.
- Tested five different FDA-approved open-field FGS systems using the proposed pipeline.
Main Results:
- The proposed pipeline successfully implemented a standardization approach for FGS systems.
- Demonstrated the feasibility of inter-system comparisons using the evaluation pipeline.
- Provided insights into essential features and performance characteristics of different FGS setups.
Conclusions:
- A robust standardization pipeline is essential for assessing FGS system performance.
- The proposed pipeline benefits regulatory agencies, manufacturers, and end-users.
- This approach aids in evaluating current systems and guiding the development of next-generation FGS technology.
