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Related Concept Videos

Fungal Phylum Microsporidia01:28

Fungal Phylum Microsporidia

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Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
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Current Models to Study the Sporothrix-Host Interaction.

Ana P Vargas-Macías1, Manuela Gómez-Gaviria1, Laura C García-Carnero1

  • 1División de Ciencias Naturales y Exactas, Departamento de Biología, Universidad de Guanajuato, Guanajuato, Mexico.

Frontiers in Fungal Biology
|September 25, 2023
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Summary
This summary is machine-generated.

Sporotrichosis, a fungal infection, is caused by Sporothrix species. This review examines various models, including invertebrates, for studying host-pathogen interactions and antifungal resistance.

Keywords:
animal modelantifungal drugsex vivo modelimmune responseinvertebrate modelpathogen-host interactionvirulence factors

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Area of Science:

  • Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Sporotrichosis is a subcutaneous mycosis caused by *Sporothrix* species, affecting mammals including humans.
  • Acquisition occurs via traumatic inoculation or zoonotic transmission, posing an emergent health problem, especially for immunocompromised individuals.
  • Different *Sporothrix* species exhibit varying virulence, host range, and antifungal sensitivity, necessitating research into pathogenesis and resistance mechanisms.

Purpose of the Study:

  • To review and analyze the different models used for studying host-*Sporothrix* interactions.
  • To highlight the advantages of alternative models over traditional mammalian models.
  • To provide insights into understanding *Sporothrix* pathogenesis, immune interactions, and antifungal resistance.

Main Methods:

  • Literature review of existing research on host-*Sporothrix* interaction models.
  • Analysis of studies utilizing mammalian models (e.g., murine models).
  • Evaluation of alternative models such as invertebrate hosts (*Galleria mellonella*, *Tenebrio molitor*) and *ex vivo* systems.

Main Results:

  • Mammalian models are the gold standard but have ethical and budgetary limitations.
  • Invertebrate and *ex vivo* models offer advantages for studying virulence, host-pathogen interactions, and antifungal resistance.
  • These alternative models facilitate research without the constraints of animal models.

Conclusions:

  • Alternative models like invertebrates and *ex vivo* systems are valuable tools for studying sporotrichosis.
  • These models aid in understanding *Sporothrix* pathogenesis, host immune responses, and antifungal drug resistance.
  • Further utilization of these models can advance sporotrichosis research, particularly for immunocompromised patients.