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Channel Behavior and Voltage Gating of a Cx43 Mutant Simulating Preconditioning

Jose F Ek-Vitorin1, Diego Silva-Mendoza1, Tasha K Pontifex1

  • 1Department of Physiology, University of Arizona, Tucson, Arizona, USA.

Bioelectricity
|September 25, 2023
PubMed
Summary

Ischemic preconditioning affects Connexin 43 (Cx43) phosphorylation. A Cx43 mutant mimicking this phosphorylation showed altered hemichannel and gap junction properties, potentially preserving cell communication during ischemia.

Keywords:
CK1Cx43PKCischemiapatch clamppreconditioning

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