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Hearing

Hearing

When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.

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Updated: Jun 25, 2026

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice

Published on: January 9, 2019

Microglia induce auditory dysfunction after status epilepticus in mice.

Tasuku Araki¹, Toshimitsu Hiragi¹, Nahoko Kuga^1,2

¹Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan.

|September 25, 2023

Summary

This summary is machine-generated.

Microglia contribute to auditory pathway dysfunction after seizures in mice by reducing inhibitory synapses. Targeting these glial cells in the thalamus may improve auditory processing in epilepsy.

Keywords:

auditory dysfunction epilepsy medial geniculate body microglia status epilepticus synaptic E/I balance synaptic stripping

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Preparation and Implantation of Electrodes for Electrically Kindling VGAT-Cre Mice to Generate a Model for Temporal Lobe Epilepsy

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Published on: August 17, 2021

Area of Science:

Neuroscience
Immunology
Epilepsy Research

Background:

Auditory dysfunction and hyperactivity in auditory pathways are observed in temporal lobe epilepsy.
The underlying cellular mechanisms, particularly the role of glia, remain unclear.

Purpose of the Study:

To investigate the role of microglia in auditory pathway disinhibition following status epilepticus in a mouse model.
To elucidate the cellular mechanisms linking microglia to auditory dysfunction in epilepsy.

Main Methods:

Induction of status epilepticus in mice.
Electrophysiological recordings and neuronal activity assessments in auditory pathways (auditory cortex, medial geniculate body).
Microglial manipulation (local removal) and assessment of synaptic changes and auditory discrimination.

Main Results:

Status epilepticus led to increased neuronal activity and impaired auditory discrimination.
Microglia were found to reduce inhibitory synapses on medial geniculate body (MGB) relay neurons post-seizure.
Removal of microglia from the MGB normalized neuronal activity and improved auditory discrimination.

Conclusions:

Thalamic microglia play a critical role in the development of auditory pathway hyperactivity and dysfunction after epilepsy.
Microglial-mediated reduction of inhibitory synapses contributes to epilepsy-associated auditory deficits.
Targeting thalamic microglia presents a potential therapeutic strategy for auditory dysfunction in epilepsy.