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Related Experiment Videos

Spontaneous abortion after transcervical chorionic villus sampling: a case report.

W E MacKenzie, D I Rushton

    Prenatal Diagnosis
    |September 1, 1986
    PubMed
    Summary

    Spontaneous abortion occurred after transcervical CVS, despite no initial signs of infection and antibiotic use. Pathological findings revealed chorioamnionitis, raising questions about infection prevention during the procedure.

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    Area of Science:

    • Obstetrics and Gynecology
    • Perinatal Medicine
    • Infectious Disease

    Background:

    • Trans-cervical chorionic villus sampling (CVS) is a common first-trimester prenatal diagnostic procedure.
    • Infection is a known risk associated with invasive procedures like CVS.

    Observation:

    • A case of spontaneous abortion following transcervical CVS is reported.
    • No vaginal or cervical bacteria were detected prior to the procedure.
    • Prophylactic Metronidazole was administered before CVS.

    Findings:

    • Despite preventative measures, pathological examination confirmed chorioamnionitis.
    • The presence of chorioamnionitis suggests an intrauterine infection occurred post-CVS.

    Implications:

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    • This case highlights the potential for intrauterine infection and subsequent pregnancy loss after CVS, even with prophylactic antibiotics.
    • Further research may be needed to understand the mechanisms of infection in such cases.
    • Review of current infection prevention protocols for transcervical CVS may be warranted.