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Three Cases of Myoclonus Secondary to Ciprofloxacin: "Ciproclonus"

Hamna Javed1, Hossam Tharwat Ali2, Ziad Ashraf Soliman2

  • 1Lahore Medical and Dental College, Lahore, Pakistan.

Clinical Neuropharmacology
|September 25, 2023
PubMed
Abstract

Insights

Ciprofloxacin, a common antibiotic, can rarely cause myoclonus (involuntary muscle jerks). Stopping the drug led to full recovery in all reported cases, suggesting a link to neurotransmitter pathways.

Area of Science:

  • Neurology
  • Pharmacology
  • Infectious Diseases

Background:

  • Ciprofloxacin is a widely used fluoroquinolone antibiotic.
  • Myoclonus is a potential adverse effect of ciprofloxacin therapy.
  • Understanding this association is crucial for patient safety.

Purpose of the Study:

  • To report cases of ciprofloxacin-induced myoclonus.
  • To review existing literature on this adverse event.
  • To investigate the clinical characteristics and outcomes.

Main Methods:

  • Chart review of three patients experiencing myoclonus after ciprofloxacin use.
  • Comprehensive literature search for similar reported cases.
  • Exclusion of other potential causes for myoclonus.

Main Results:

  • Three cases of myoclonus developed within three days of ciprofloxacin initiation, typically for urinary tract infections.
  • Neurological assessments including EEG and neuroimaging were normal.
  • Cessation of ciprofloxacin resulted in complete recovery for all patients.

Conclusions:

  • Ciprofloxacin is a probable cause of myoclonus in susceptible individuals.
  • The mechanism may involve disruption of GABA and glutamate pathways.
  • Prompt drug withdrawal is an effective management strategy.

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