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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Combatting resistance: Understanding multi-drug resistant pathogens in intensive care units

Jianying Teng1, Saber Imani2, Aiping Zhou3

  • 1Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou, Zhejiang 310015, PR China; The Affiliated Hospital of Stomatology, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, Zhejiang 310000, PR China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|September 25, 2023
PubMed

Insights

Antibiotic resistance is a growing crisis, especially multi-drug resistant (MDR) pathogens in Intensive Care Units (ICUs). This review analyzes MDR ESKAPE pathogens, their resistance, and control strategies to combat these infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Public Health

Background:

  • Antibiotic misuse drives the spread of drug-resistant bacteria, creating a global healthcare crisis.
  • Multi-drug resistant (MDR) opportunistic pathogens, particularly ESKAPE pathogens, are prevalent in Intensive Care Units (ICUs), increasing morbidity and mortality.
  • These MDR pathogens pose a significant threat in healthcare settings.

Purpose of the Study:

  • To analyze the current prevalence of MDR opportunistic pathogens in ICUs.
  • To investigate the resistance mechanisms of MDR ESKAPE pathogens against key antibiotics.
  • To explore innovative strategies for preventing and controlling antibiotic resistance.

Main Methods:

  • Comprehensive literature review of MDR opportunistic pathogens in ICUs.
  • Analysis of resistance mechanisms against polymyxins, carbapenems, and tigecycline.
  • Exploration of current and novel control strategies for antibiotic resistance.

Main Results:

  • MDR opportunistic pathogens, especially ESKAPE pathogens, are highly prevalent in ICUs.
  • Detailed insights into resistance mechanisms against critical antibiotics are provided.
  • Various innovative strategies for resistance prevention and control are discussed.

Conclusions:

  • Urgent implementation of robust measures is crucial to combat nosocomial infections caused by MDR pathogens in ICUs.
  • This review serves as a vital reference for future research on antibiotic resistance.
  • Addressing MDR pathogen spread in ICUs is essential for public health protection.
Keywords:
ESKAPE pathogensMulti-drug resistant opportunistic pathogensNosocomial infectionsPrevalence situationResistance mechanismsTherapeutic strategies

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