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Hemodynamic effects of PAF-acether.

G E Plante, R L Hebert, C Lamoureux

    Pharmacological Research Communications
    |August 1, 1986
    PubMed
    Summary

    Platelet-activating factor (PAF) causes hypotension and reduced kidney blood flow. While prostaglandins mediate some effects, angiotensin II is key to PAF

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    Area of Science:

    • Pharmacology
    • Renal Physiology
    • Cardiovascular Research

    Background:

    • Platelet-activating factor (PAF) induces plasma extravasation and systemic hypotension.
    • PAF administration leads to reduced blood flow in vital organs, including the kidneys.
    • The roles of cyclo-oxygenase metabolites and angiotensin II in PAF's hemodynamic and renal effects are not fully understood.

    Purpose of the Study:

    • To investigate the involvement of cyclo-oxygenase metabolites and angiotensin II in the hemodynamic and renal consequences of PAF-Acether injection.
    • To elucidate the specific mechanisms by which PAF affects renal hemodynamics and sodium excretion.

    Main Methods:

    • Administration of PAF-Acether to subjects.
    • Treatment with indomethacin (a cyclo-oxygenase inhibitor) alone and in combination with saralasin (an angiotensin II receptor blocker).
    • Measurement of arterial blood pressure, glomerular filtration rate (inulin clearance), renal plasma flow (PAH clearance), and urinary sodium excretion.

    Main Results:

    • Indomethacin prevented the fall in arterial blood pressure but not the reduction in glomerular filtration, renal plasma flow, or urinary sodium excretion.
    • Combined indomethacin and saralasin treatment prevented the decrease in glomerular filtration and renal plasma flow during PAF infusion.
    • The combined treatment did not prevent the significant fall in urinary sodium excretion.

    Conclusions:

    • Peripheral vascular effects of PAF-Acether depend on vasodilatory prostaglandins.
    • In the kidney, PAF-induced reductions in renal hemodynamics are mediated by angiotensin II, not prostaglandins.
    • The dissociation between renal hemodynamics and sodium excretion under PAF suggests complex regulatory mechanisms requiring further investigation.

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