Adrenocortical responsiveness to novelty in the hamster

The adrenocortical response to increasing periods of exposure to a novel cage, as well as the effects of returning hamsters to their familiar home cages, were examined. We found that a five min exposure to a novel cage was insufficient to activate the pituitary-adrenal system, but that cortisol levels increased significantly as duration of exposure increased from 15 to 30 min. In contrast, returning hamsters to their home cages for at least 15 min following the 15 min novel cage exposure produced a significant drop in plasma levels of cortisol. Finally we found that males exhibit a greater cortisol response to novelty than females, indicating a sexual dimorphism which is the reverse of that reported in other rodents.