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Author Spotlight: Understanding and Detecting Environmental Antimicrobial Resistance by Combining Culture-Based Techniques and Genomics
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Genomic surveillance for antimicrobial resistance - a One Health perspective

Steven P Djordjevic1,2, Veronica M Jarocki3,4, Torsten Seemann5,6

  • 1Australian Institute for Microbiology and Infection, University of Technology Sydney, Sydney, New South Wales, Australia. steven.djordjevic@uts.edu.au.

Nature Reviews. Genetics
|September 25, 2023
PubMed

Insights

Antimicrobial resistance (AMR) surveillance requires a One Health approach, integrating human, animal, and environmental data. Genomic technologies are advancing AMR gene monitoring, pathogen tracing, and evolution modeling to combat this global threat.

Area of Science:

  • Microbiology
  • Genomics
  • Public Health

Background:

  • Antimicrobial resistance (AMR) is a complex threat influenced by interactions across humans, animals, and the environment.
  • A 'One Health' approach is crucial for understanding and managing AMR's impact on health and security.
  • Genomic technologies offer powerful tools for AMR surveillance.

Purpose of the Study:

  • To highlight advances in genomic AMR surveillance.
  • To compare the strengths of different genomic technologies for AMR research.
  • To showcase insights from One Health genomic surveillance and discuss adoption challenges.

Main Methods:

  • Utilizing genomic technologies to monitor AMR genes and mutations.
  • Applying source-tracing of AMR pathogens.
  • Modeling AMR evolution and transmission dynamics.

Main Results:

  • Genomic technologies enable effective monitoring of AMR gene mobilization, persistence, and abundance.
  • Source-tracing and transmission modeling of AMR pathogens are enhanced by genomic data.
  • Recent insights from One Health genomic surveillance have been identified.

Conclusions:

  • Genomic surveillance is vital for a comprehensive One Health approach to AMR.
  • Technological advancements are improving AMR monitoring and understanding.
  • Broader adoption of genomic surveillance faces challenges in diverse economic settings.

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