Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cognitive Dissonance01:38

Cognitive Dissonance

32.7K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
32.7K
Radical Formation: Overview01:03

Radical Formation: Overview

2.1K
A bond can be broken either by heterolytic bond cleavage to form ions or homolytic bond cleavage to yield radicals. A fishhook arrow is used to represent the motion of a single electron in homolytic bond cleavage. There are two main sources from which radicals can be formed:
Radicals from spin-paired molecules:
Radicals can be obtained from spin-paired molecules either by homolysis or electron transfer. While two radicals are formed in the former, an electron is added in the...
2.1K
Motivational Cycle01:20

Motivational Cycle

628
The motivational cycle is a key concept that explains how individuals are motivated to meet their needs. At its core, the cycle revolves around four distinct stages: need, drive, goal-directed behavior, and goal achievement. These stages respond to imbalances in the body or mind, prompting actions that restore balance.
The cycle begins with a need. This need can arise from various conditions, such as hunger, thirst, or temperature changes. For instance, when an individual feels cold, their body...
628
Radical Formation: Elimination00:51

Radical Formation: Elimination

1.7K
Another method of radical formation is the elimination process. It is the opposite of the addition route and is driven by the instability of the radical. For example, as depicted in Figure 1, dibenzoyl peroxide yields a pair of unstable radicals upon homolysis. Given its instability, this radical spontaneously undergoes elimination via a C–C bond cleavage to form a relatively more stable phenyl radical. The mechanism involves cleavage of the bond between the α and β positions...
1.7K
Group Design02:01

Group Design

9.0K
The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
9.0K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.6K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Menopausal Hormone Labels Should Rely on Evidence, Not Opinion.

JAMA·2026
Same author

Determinants of publication likelihood and timeliness for clinical studies.

Journal of clinical and translational science·2026
Same author

Distal Radius Interventions for Fracture Treatment (DRIFT) trial: study protocol for a multicentre randomised clinical trial of completely translated distal radius fractures at paediatric hospitals in North America.

BMJ open·2025
Same author

Decentralized Clinical Trials in the Era of Real-World Evidence: A Critical Assessment of Recent Experiences.

Clinical and translational science·2025
Same author

SPIRIT 2025 statement: updated guideline for protocols of randomised trials.

BMJ (Clinical research ed.)·2025
Same author

SPIRIT 2025 explanation and elaboration: updated guideline for protocols of randomised trials.

BMJ (Clinical research ed.)·2025

Related Experiment Video

Updated: Jul 15, 2025

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

4.3K

Training New DMC Members: A Call to Action.

Frank Rockhold1,2, Kenneth Mahaffey3, David DeMets4

  • 1Duke University Medical Center, Durham, USA. frank.rockhold@duke.edu.

Therapeutic Innovation & Regulatory Science
|September 25, 2023
PubMed
Summary
This summary is machine-generated.

A growing need for trained Data Monitoring Committee (DMC) members exists due to increased clinical trials. The study proposes on-the-job training for new members within actual trials to bridge this gap.

Keywords:
ApprenticeData Monitoring CommitteesMentoringTraining, Mentoring

More Related Videos

Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation
06:23

Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation

Published on: March 9, 2018

5.6K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K

Related Experiment Videos

Last Updated: Jul 15, 2025

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum
04:36

Setup and Execution of the Rapid Cycle Deliberate Practice Death Notification Curriculum

Published on: August 5, 2020

4.3K
Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation
06:23

Preparation of DMMTAV and DMDTAV Using DMAV for Environmental Applications: Synthesis, Purification, and Confirmation

Published on: March 9, 2018

5.6K
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

11.9K

Area of Science:

  • Clinical Trials
  • Biostatistics
  • Regulatory Science

Background:

  • Historically, expertise in Data Monitoring Committees (DMCs) was acquired through on-the-job training.
  • A significant and increasing gap between the demand for and supply of trained DMC members has been identified.
  • This shortage is partly attributed to the substantial rise in the number of ongoing clinical trials.

Purpose of the Study:

  • To address the critical need for more clinicians and biostatisticians trained in DMC operations.
  • To propose a practical training approach for individuals lacking prior DMC experience.

Main Methods:

  • Leveraging existing training materials and recommending a mentoring process.
  • Proposing the inclusion of investigators new to DMC responsibilities as members of actual DMCs.
  • Facilitating learning of DMC processes through direct participation in ongoing trials.

Main Results:

  • The proposed method allows for practical, real-time training in DMC procedures.
  • This approach aims to increase the pool of qualified DMC members.
  • It supports the development of expertise for clinical trialists and data scientists.

Conclusions:

  • Academic, regulatory, and industry leaders should endorse the inclusion of inexperienced investigators in DMCs.
  • This practical training strategy can effectively address the shortage of skilled DMC personnel.
  • Integrating new members into active trials offers a viable solution for DMC member development.