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Quantitative dynamic contrast-enhance MRI parameters for rectal carcinoma characterization: correlation with tumor
Jie Yuan1, Kun Liu2, Yun Zhang3
1Department of Radiology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
World Journal of Surgical Oncology
|September 25, 2023
Summary
Dynamic contrast-enhanced MRI parameters correlate with rectal cancer composition. These imaging biomarkers can help identify tumor tissue components, aiding in diagnosis and treatment planning.
Area of Science:
- Radiology
- Oncology
- Pathology
Background:
- Rectal carcinoma characterization is crucial for treatment planning.
- Dynamic contrast-enhanced MRI (DCE-MRI) offers quantitative insights into tumor microvasculature.
- Understanding the relationship between DCE-MRI parameters and histological composition is essential for improving diagnostic accuracy.
Purpose of the Study:
- To investigate the correlation between DCE-MRI derived quantitative parameters and the histological composition of rectal cancer.
- To explore the potential of DCE-MRI as an imaging biomarker for identifying specific tumor tissue components.
Main Methods:
- Twenty-four rectal cancer patients underwent DCE-MRI prior to surgery.
- Quantitative parameters (e.g., Ktrans, Ve, Kep, MTT) were derived using a modified Tofts model.
- Histological analysis, including immunohistochemistry and Masson staining, quantified tissue components and biomarkers (e.g., CD34, vimentin, CDX-2, Ki-67).
- Pearson correlation analysis assessed relationships between DCE-MRI and pathological parameters.
Main Results:
- Significant differences in DCE-MRI parameters (Ktrans, MTT) and histological markers (CDX-2, Ki-67) were observed across different World Health Organization (WHO) tumor grades.
- Extracellular extravascular space (ECV) showed significant differences related to extramural venous invasion.
- Ktrans and Kep demonstrated strong positive correlations with CD34 expression.
- Ve correlated positively with Masson's staining and vimentin, and negatively with CDX-2.
- ECV showed a moderate negative correlation with CDX-2 and a positive correlation with collagen fibers.
Conclusions:
- DCE-MRI derived parameters are significantly correlated with the proportion of histological components in rectal cancer.
- These findings suggest DCE-MRI can serve as a valuable, non-invasive imaging biomarker for characterizing rectal tumor composition.
- This could lead to improved diagnostic capabilities and personalized treatment strategies for rectal cancer.
