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Related Experiment Video

Updated: Jul 15, 2025

Assessing Hepatic Metabolic Changes During Progressive Colonization of Germ-free Mouse by 1H NMR Spectroscopy
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Human gut microbiome and metabolite dynamics under simulated microgravity.

Ana Ramos-Nascimento1, Lucia Grenga2, Sven-Bastiaan Haange3

  • 1Institute of Aerospace Medicine, German Aerospace Center (DLR e.V.), Cologne, Germany.

Gut Microbes
|September 26, 2023
PubMed
Summary

Simulated weightlessness mildly altered the gut microbiome in astronauts. Countermeasure protocols increased beneficial short-chain fatty acids, suggesting a way to maintain gut health during spaceflight.

Keywords:
AGBRESAGut microbiomeSCFAbed rest studyfunctional analysisgut metabolitesmetaproteomicsmicrogravityspaceflight

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Area of Science:

  • Space medicine
  • Microbiome research
  • Human physiology

Background:

  • Long-duration spaceflight poses risks to human health, including alterations to the gut microbiome.
  • Simulated microgravity via bed rest is a key analog for studying these effects.
  • Artificial gravity is being explored as a potential countermeasure.

Purpose of the Study:

  • To investigate the impact of 60-day simulated microgravity on the gut microbiome.
  • To assess the effectiveness of artificial gravity as a countermeasure for gut microbiome changes.
  • To identify microbial and metabolic signatures associated with simulated weightlessness and countermeasures.

Main Methods:

  • 12 participants underwent 60-day head-down tilt bed rest.
  • Fecal samples were analyzed for gut microbiome composition and function.
  • Metabolite profiling focused on short-chain fatty acids (SCFAs).

Main Results:

  • Simulated microgravity induced mild changes in the gut microbiome composition and pathway expression.
  • Countermeasure protocols led to distinct microbial patterns compared to the microgravity-only group.
  • Beneficial SCFAs like acetate, butyrate, and propionate were selectively increased by countermeasures.
  • Modulation of beneficial and opportunistic taxa indicated a mild adaptation in microbiome balance.

Conclusions:

  • Gut microbiome monitoring, pathway analysis, and metabolite profiling offer a synergistic approach to assess health during space missions.
  • Countermeasure protocols show promise in mitigating negative gut microbiome alterations.
  • Findings support strategies for maintaining astronaut gut health in microgravity environments.