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Updated: Jul 15, 2025

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
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Marfan Syndrome, Giant Ascending Aortic Aneurysm, and Left Ventricular Noncompaction: The Heart in Jeopardy!

Najlaa Belharty1, Selma Siagh1, Tanae El Ghali1

  • 1Department of Cardiology B, Ibn Sina Hospital, Mohammed V University, Rabat, MAR.

Cureus
|September 26, 2023
PubMed

Insights

Marfan syndrome (MFS), a genetic disorder, can unusually present with left ventricular noncompaction (LVNC). This case highlights the severe cardiac complications of MFS, including aortic aneurysms and LVNC.

Area of Science:

  • Cardiology
  • Genetics
  • Connective Tissue Disorders

Background:

  • Marfan syndrome (MFS) is a heritable connective tissue disorder caused by FBN1 gene mutations.
  • Cardiovascular complications, particularly thoracic aortic aneurysms, are primary concerns in MFS.
  • Left ventricular noncompaction (LVNC) is an uncommon but significant cardiac manifestation in MFS.
Keywords:
aortic aneurysmaortic regurgitationcardiogenic shockleft ventricular non compactionmarfan syndrome

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