Related Experiment Video

Updated: Aug 17, 2026

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
09:09

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Published on: August 9, 2013

A nonlinear tissue-binding model for creatine: estimation of creatine turnover time and creatinine production rate

M Boroujerdi

    Research Communications in Chemical Pathology and Pharmacology
    |September 1, 1986
    PubMed

    More Related Videos

    Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging11:43

    Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

    Published on: December 30, 2016

    Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain06:31

    Quantitative [18F]-Naf-PET-MRI Analysis for the Evaluation of Dynamic Bone Turnover in a Patient with Facetogenic Low Back Pain

    Published on: August 8, 2019

    Related Concept Videos

    One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

    One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

    This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
    On...
    Three-Compartment Open Model01:06

    Three-Compartment Open Model

    The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...
    Model Approaches for Pharmacokinetic Data: Physiological Models01:15

    Model Approaches for Pharmacokinetic Data: Physiological Models

    Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
    Physiological Pharmacokinetic Models: Assumption with Protein Binding01:13

    Physiological Pharmacokinetic Models: Assumption with Protein Binding

    Physiological models with protein binding in pharmacokinetics offer a sophisticated approach to understanding drug disposition. These models consider drug-protein interactions, enabling them to effectively predict drug concentrations in different organs and tissues. This precision aids in accurate drug dosing, providing a significant advantage over conventional models. A key process within these models is equilibration, which ensures that drug concentrations achieve a steady state within the...
    Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance01:25

    Drug Dosing in Renal Diseases: Measurement of Serum Creatinine Concentration and Clearance

    In healthy individuals, serum creatinine levels remain stable due to a balance between its constant production—primarily from muscle metabolism—and renal excretion. Creatinine is freely filtered by the glomeruli, making it a valuable marker for estimating renal function. When the glomerular filtration rate (GFR) decreases, the kidneys can only eliminate less creatinine, causing serum levels to rise.Serum creatinine concentration is widely used to estimate creatinine clearance (Clcr), a...
    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

    Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

    Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area. This equation is...