Related Experiment Video
Updated: Jul 15, 2025
07:50
Global and Current Research Trends of Single-Cell Sequencing in Cancer: A Bibliometric and Visualization Study
Published on: April 18, 2025
227
Global trends in PANoptosis research: bibliometrics and knowledge graph analysis
Yi Zheng1,2, Jiachen Li1,2, Bo Liu1,2
1Department of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Apoptosis : an International Journal on Programmed Cell Death
|September 26, 2023
Summary
PANoptosis, a novel cell death pathway, involves apoptosis, necroptosis, and pyroptosis. Research is rapidly advancing, with a growing focus on its role in cancer and inflammation, particularly in tumor treatment.
Area of Science:
- Cellular Biology
- Immunology
- Biomedical Research
Background:
- PANoptosis is a newly identified programmed cell death pathway.
- It integrates apoptosis, necroptosis, and pyroptosis.
- Systematic literature analysis on PANoptosis is limited.
Purpose of the Study:
- To perform a bibliometric analysis of PANoptosis research.
- To identify research hotspots and predict future trends.
- To visualize the evolution of PANoptosis research from 2016 to 2022.
Main Methods:
- Bibliometric analysis using Histcite Pro 2.0.
- Visualization of trends and hotspots using VOSviewer and CiteSpace.
- BioBERT language model for gene and disease mining.
Main Results:
- Low publication volume from 2016-2020, followed by exponential growth (2020-2022).
- The United States and China are leading research nations, with China showing rapid development.
- Research focus shifted towards PANoptosis mechanisms in cancer and inflammation, particularly in tumor treatment.
Conclusions:
- PANoptosis research is in a rapid development stage.
- Current hotspots include PANoptosis mechanisms in cancer and inflammation, with increasing focus on NLRC4, NLRP3, and Gasdermin D.
- Future research directions include exploring PANoptosis in treating inflammation-related diseases and tumors.
Related Concept Videos
02:02Genomics
36.4K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.4K
01:25Glaucoma: Overview
614
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
614
01:30Current Trends in Nursing II
1.2K
Trends in nursing are multifactorial and associated with changes in society, within the nursing profession, and in other professions. Notably, telehealth and remote nursing contribute to successful healthcare delivery for numerous patients and help reduce stress for nurses due to nursing shortages. Nurses can reach patients, monitor their conditions, and interact with them using computers, audio, visual accessories, and telephones—for example, remote patient monitoring systems. Likewise,...
1.2K
02:34Empathy
9.6K
Some researchers suggest that altruism operates on empathy. Empathy is the capacity to understand another person’s perspective, to feel what he or she feels. An empathetic person makes an emotional connection with others and feels compelled to help (Batson, 1991). Empathy can be expressed in several ways, including cognitive, affective, and motor.
9.6K
01:12Hindsight Biases
3.4K
Hindsight bias leads you to believe that the event you just experienced was predictable, even though it really wasn’t. In other words, you knew all along that things would turn out the way they did. Can you relate this to the phrase "Hindsight is 20/20" now?
3.4K
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K